Alphitolic acid (30) showed an effect quite similar to that of dexamethasone in inhibition of the nuclear factor kappa-B (NF-κB), or suppressing the secretion of pro-inflammatory cytokines such as cytokines suppressor effect of alphitolic acid (30) can help in reducing the severe inflammatory syndrome associated with COVID-19. The gene discussed is NFKB1; the disease is COVID-19.