The increase of plasma levels of sEng has been described in different animal models of preeclampsia such as placental ischemia in pregnant rats due to the reduction of uterine perfusion (RUPP) [7] or feto-placental expression of the transcription factor STOX1 in transgenic mice [48], both characterized by the presence of placental abnormalities [49]. This evidence concerns the gene STOX1 and preeclampsia.