Since the tumor suppressor p53, in all its multiple roles, is widely invoked in many conditions ranging from cancer to aging and age-related diseases [11,43,44], we report the results of plasma U-p532D3A8+ tested in 114 elderly patients affected by different chronic diseases and multi-morbidities recruited in the population-based study ANZIANI IN-RETE [34]. The gene discussed is TP53; the disease is cancer.