Using streptozotocin (STZ)-induced diabetic ApoE2/2 mice, a well-established model for the study of human atherosclerosis metformin has be found to reduce dynamin-related protein 1 (Drp1) expression and Drp1-mediated mitochondrial fission in an AMPK-dependent manner. The gene discussed is PRKAA2; the disease is atherosclerosis.