Remarkably, the S protein of human coronaviruses including, NL63 [75], SARS-CoV [76] and SARS-CoV-2 [16] can also employ angiotensin-converting enzyme 2(ACE2) as an entry receptor for infection, suggesting that both ACE2 and the lectin family proteins, CD209L and CD209, contribute to the spread of these pathogens in vivo. The gene discussed is PROS1; the disease is infection.