MMP8 and gestational diabetes: However, when examining the changes in the levels of hsCRP, phIGFBP-1, IGFBP-1 or MMP-8 during pregnancy according to the diagnosis of GDM, the concentration of hsCRP was reduced from early to late pregnancy to a greater extent in the women who developed GDM (natural log-transformed mean change −0.47 (95%CI −0.62 to −0.33) mg/L) than in the women who remained healthy (natural log-transformed mean change −0.25 (95%CI −0.33 to −0.17) mg/L, p = 0.01).