In line with this, we measured in three PCa cell lines, before/after MALAT1 silencing, the mRNA level of the peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha, a member of a family of transcription coactivators that plays a central role in the regulation of cellular energy metabolism [30]. The gene discussed is MALAT1; the disease is posterior cortical atrophy.