IEDB analysis showed that those BTVs (serotypes 2, 8, 11, and 17) with records of an allergy, manifested by IL-4 expression, had significantly higher numbers of potential IL-4-inducing peptides (segments) on the whole length of VP2 than those BTVs (serotypes 12, 1) without allergy records (Table 1 and Table S1), averaging 24.80 ± 2.713 segments (n = 20) versus 19.80 ± 2.926 segments (n = 15) (p < 0.01), respectively. This evidence concerns the gene IL4 and allergic disease.