ERBB2 and breast cancer: Downregulation of HER2/HER3 signaling by miR-205 was also demonstrated by Wang S. et al. Indeed, they reported that an HDAC inhibitor, entinostat, specifically enhances the expression of miR-125a, miR-125b, and miR-205, which act together to downmodulate HER2/HER3, thus inducing apoptosis in breast cancer cells [25].