Recently, Wang’s group demonstrated that miR-205 targets high mobility group box 1 (HMGB1) in the MDA-MB-231 TNBC cell line and this axis suppresses the EMT process; in particular, they showed that the re-introduction of miR-205 inhibited HMGB1/RAGE (receptor for advanced glycation end products) expression, resulting in the suppression of tumor invasion and EMT [29]. The gene discussed is HMGB1; the disease is neoplasm.