In fact, two major LCNEC subsets had previously been identified [25] based on their profile of altered genes, one considered SCLC-like, with frequent TP53/RB1 mutations, and the other nonSCLC-like, with frequent TP53/STK11/KEAP1/KRAS mutations. The gene discussed is KEAP1; the disease is large cell neuroendocrine carcinoma.