In osteosarcoma, HOTAIR suppression significantly reduces the migration and invasion, decreases the expression of MMP-2 and MMP-9 and increases the expression of CDH1. This occurs through regulation of RAC-α serine/threonine protein kinase target in rapamycin signalling pathway [122], whereas in gliomas, this lncRNA increases MMP-7 and MMP-9 expression by upregulating the Wnt/β-catenin pathway [123]. This evidence concerns the gene MMP9 and central nervous system cancer.