In breast cancer, HOXB7 overexpression can promote tumour migration and invasion through the induction of EMT in epithelial cells, by reducing the expression of epithelial proteins, as Claudin-1 and Claudin-7, together with mislocalisation of Claudin-4 and CDH1 and increased expression of mesenchymal proteins: vimentin and alpha-smooth muscle actin (α-SMA) [82] (Figure 4). This evidence concerns the gene HOXB7 and breast carcinoma.