Another antivasculogenic molecule, the biciclame compound plerixafor (AMD3100), was able to inhibit irradiation-induced vasculogenesis in vivo by preventing the binding of the chemokine stromal cell-derived factor 1 (SDF-1, involved in the migratory process of GBM) to its receptor C-X-C chemokine receptor type 4 (CXCR4) [59]. This evidence concerns the gene CXCL12 and glioblastoma.