To establish if different amounts of FOXE1 could result in different outcomes in thyroid tumorigenesis, we generated a mouse model of thyroid cancer harboring only one functional FOXE1 allele by crossing the heterozygous FOXE1 knockout mouse line [16] with a well-established model of thyroid cancer, in which a BRAFV600E oncogene is expressed in a thyroid-specific and Dox-inducible manner [15]. This evidence concerns the gene FOXE1 and thyroid gland carcinoma.