Of special interest here are genes more closely related to the tumor immune response, such as CXCL8, which encodes for the chemokine IL-8 with a central role in regulating the innate immune response [24] as well as the ICOSLG gene which encodes for the Inducible T Cell Costimulator Ligand (CD275 or B7H2) [25]. The gene discussed is ICOSLG; the disease is neoplasm.