Curcumin can impair extrapyramidal symptoms and increased HO-1 expression through Akt/Nrf2 phosphorylation in the substantia nigra pars compacta of rats treated with rotenone, a pharmacological tool able to destroy dopaminergic neurons and therefore, used to induce experimental Parkinson’s disease (PD) [56]. The gene discussed is AKT1; the disease is Parkinson disease.