The decreased expression of bcl-2, and DNA repair enzymes, such as O-6-Methylguanine-DNA Methyltransferase (MGMT), lead to reduced resistance of glioma cells against radiation and chemotherapeutic agents; this suggests that curcumin may be a potential useful adjuvant for common chemotherapeutic agents and radiation [95,96]. The gene discussed is MGMT; the disease is glioma.