Similarly, a study showed that miR-100-rich human MSCs exosomes reduced the expression of VEGF in breast cancer (MCF-7 and MDA-MB-231) in a dose-dependent manner by modulating mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1α (HIF-1α) signaling [85]. The gene discussed is VEGFA; the disease is breast carcinoma.