Andrographolide reduces MMP-1, MMP-3, and MMP-9 expression of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) in hypoxia, decreasing HIF-1α expression and interfering with HIF-1α binding to DNA (Figure 3) [47]. The gene discussed is HIF1A; the disease is rheumatoid arthritis.