Moreover, andrographolide antagonizes TNF-α-induced IL-8 via inhibition of the NADPH oxidase/ROS/NF-κB and Src/MAPKs/AP-1 axes (Figure 1) in human colorectal cancer HCT116 cells and suppresses angiogenesis in the tumor microenvironment [22]. Here, CXCL8 is linked to colorectal cancer.