The JAK/STAT pathway controls the expression of key glycolytic mediators 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), PDK-1, HK-2, glycogen synthase kinase-3α (GSK-3α), and GLUT-1, an effect paralleled by the activation of proinflammatory, proangiogenic, and invasive mechanisms in RA (Figure 3) [77]. This evidence concerns the gene PFKFB3 and rheumatoid arthritis.