A reduction of AMPK phosphorylation has been observed in FLS isolated from rats with arthritis; conversely, the glycolysis inhibitor 2-deoxyglucose (2-DG) increases AMPK phosphorylation, interfering with the NF-κB pathway, reducing pro-inflammatory cytokine release [114], and supporting the role of glycolysis in joint inflammation. The gene discussed is NFKB1; the disease is Arthritis.