Given that inflammation and the JAK/STAT3 signaling pathway are potential mechanisms associated with PM10, we hypothesized that inhalation of the essential oil derived from the Mentha genus, peppermint oil, could inhibit the epithelial remodeling and inflammation in asthma via regulation of IL-6/JAK2/STAT3 signaling pathway according to the network pharmacological analysis. This evidence concerns the gene STAT3 and asthma.