Tg significantly enhanced expression of JNK signaling-related genes (JNK, ATF6, PERK, LC3B, and Bcl-2) and proteins (JNK, MAPK, ERK) and their phosphorylated forms, suggesting activation of JNK/MAPK/ERK signaling pathway in Tg-induced apoptosis in ACC [44]. This evidence concerns the gene MAPK8 and adrenal cortex carcinoma.