In addition, to explore the diagnostic and prognostic value of serum AnxA2 levels in breast cancer patients, we examined the expression of serum AnxA2 levels in different subtypes of breast cancer patients and normal healthy females by enzyme-linked immunosorbent assay (ELISA), and evaluated the expression of serum AnxA2 levels with diagnosis and prognosis of breast cancer patients. The gene discussed is ANXA2; the disease is breast carcinoma.