AnxA2 is overexpressed in tumor tissues of both invasive ductal mammary carcinoma and ductal carcinoma in situ compared to normal and hyperplastic ductal epithelial cells and ductal complexes, suggesting a crucial role of AnxA2 in breast tumor malignancy and invasiveness [24,25,26,27,28]. Here, ANXA2 is linked to ductal breast carcinoma in situ.