In the present study, we observed that the prognostic value of serum AnxA2 in comparison to normal healthy females is very high in TNBC (AUC = 0.951, p < 0.0001) compared to ER+ (AUC = 0.427, p = 0.1830) and HER2+ (AUC = 0.783, p < 0.0001) breast cancer patients. This evidence concerns the gene ERBB2 and breast cancer.