Besides the major modes of actions of oral synthetic urolithin-A application, our results further underline the important role of LOS mediated innate immune activation in C. jejuni induced enteritis and the feasibility of the here applied acute microbiota-depleted IL-10−/− mouse model for the preclinical evaluation of future treatment options in acute campylobacteriosis. The gene discussed is IL10; the disease is campylobacteriosis.