BCL2 and infection: For example, the Bcl-2 homolog of Epstein Barr Virus (EBV) BHRF1 has 17.5% shared identity with human Bcl-xL with homologous residues clustering in BH motifs, whereas the myxoma virus homolog M11L shares only 9.6% and features no obvious BH motifs [37], however, both vBcl-2 homologs adopt the canonical Bcl-2 fold, obstruct premature host cell death, and are critical for successful infection and proliferation [40].