Furthermore, it was shown to function as a potent transactivator of different genes introduced into cells by transfection or infection, including the viral thymidine kinase (TK) gene and ICP6 gene, the human immunodeficiency virus (HIV) LTR, and several human papillomavirus (HPV) genes [41,42,43,44,45,46,47,48,49,50]. The gene discussed is TKT; the disease is infection.