Different types of EV (e.g., exosomes, microvesicles, ectosomes) are able to secrete misfolded assemblies of pathological proteins, such as the prion protein PrP, α-synuclein or Tau and contribute to their prion-like spreading pattern in various neurodegenerative diseases (e.g., Creutzfeldt–Jakob, Parkinson’s, Alzheimer’s diseases) [111,112,113,114,115]. This evidence concerns the gene PRNP and neurodegenerative disease.