Moreover, the muscle defects are transmitted systemically through muscle release of fibroblast growth factor 21 (FGF21), together with inflammatory cytokines such as interleukin 6 (IL6) inducing hypoglycemia, lipolysis, liver steatosis, inflammation, a pro-senescent phenotype, and premature death [45,60]. Here, FGF21 is linked to Hypoglycemia.