Indeed, Guo et al. reported that more than 70% idiopathic MGN patients were positive for PLA2R antibody and that the titer of serum anti-PLA2R antibody was correlated with urine proteinuria and serum albumin levels of pre- and post- therapeutic values in idiopathic MGN patients, suggesting that serum anti-PLA2R antibody may guide clinical diagnosis and treatment as well as the prognostic clues [31]. The gene discussed is PLA2R1; the disease is idiopathic membranous glomerulonephritis.