MAPKAPK2 and infection: In addition, although the role of MAPKAPK2 in the modulating B cell proliferation during infection is poorly studied, the use of SB203580 was shown to reduce Dengue virus-induced liver inflammation and tissue injury by decreasing MAPKAPK2-dependent cytokine (TNFα, IL6, and IL10) and chemokine (RANTES and IP-10) production [66].