MT3 and astrocytoma (excluding glioblastoma): Metallothionein-3 (MT3, uniprot accession P25713) is one of those proteins calculated to be statistically higher in CUSA A- zone, and the MT3 gene has been reported to be highly expressed in GBM compared to lower grade astrocytomas, and to correlate with lower prognosis of survival (p-value <0.05) [34], hence its characterization in CUSA A- would be consistent with a pathological index for GBM.