This role is also reported by Wei et al. [27], discussing all the pathological roles of osteopontin upregulation in GBM, which includes promotion of angiogenesis through modulation of COX-2 expression, myeloid-derived suppressor cell expansion through the activation of STAT3 pathway and suppression of antitumor immunity by promoting extramedullary myelopoiesis [27]. Here, SPP1 is linked to glioblastoma.