IL1B and type 1 diabetes mellitus: Yet, because the combination of these two cytokines provides a more faithful model for islet inflammation in Type 1 diabetes, where both innate and adaptive cytokine networks are involved, and since activation of both the IL-1 and IFN-γ receptor yields the relevant signaling background for the action of the employed inhibitors, affecting pathways where synergy or additive effects have been described, the combination of the two cytokines was used in the mechanistic experiments.