ACKR4 and villous adenoma: Even though ACKR4 expression in normal mucosa as compared to corresponding patient-matched polyps was not significantly different on average (Figure 1b), it was significantly lower in tubular adenomas (by 11.4-fold) and tubulovillous adenomas (by 1.8-fold) and significantly higher (by 15.8-fold) in a subgroup of patients with villous adenomas (Figure 3).