In light of growing interest in inflammation resolution as a potential antineoplastic strategy and scarcity of data concerning ACKR expression, the aim of the present study was the analysis of transcriptional patterns of ACKR2 and ACKR4 in adenoma-carcinoma sequence in the colorectum in reference to pathological findings and expression of receptors’ ligands. This evidence concerns the gene ACKR4 and adenoma.