The promising curcumin analogue L48H37 not only induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells [24] but also exerts a potent anti-cancer effect in human pancreatic ductal adenocarcinoma cells, which is augmented by histonelysine N-methyltransferase 2D [25]. Here, STAT3 is linked to pancreatic ductal adenocarcinoma.