CASP3 and osteosarcoma: In human osteosarcoma SJSA and U2OS cell lines, a structure-based curcumin analogue, FLLL32, simultaneously decreases STAT3 DNA-binding activity, and expression of survivin, VEGF, and MMP-2 at both mRNA and protein levels, with concurrent decreases in phosphorylated and total STAT3, to promote loss of cell proliferation, leading to caspase-3-dependent apoptosis [36].