STAT3 and neoplasm: The diverse MAPK members PI3K/Akt and STAT3 are activated in response to various extracellular stimuli and have distinct downstream targets, including cell motility, migration, invasion, proteinase induction, and angiogenesis, which all contribute to metastasis [31,32,33,34,35], so they have been implicated as oncogenes and therapeutic targets in a variety of neoplastic diseases.