MMP2 and cancer: Of these proteases, urokinase-type plasminogen activator (uPA), matrix metalloproteinase (MMP)-2 (gelatinase A, 72 kDa), and MMP-9 (gelatinase B, 92 kDa) are considered the most crucial enzymes for controlling the degradation of the main constituent of the ECM and are substantially involved in cancer invasion, migration, and metastasis [11,12].