HMGB1 and neoplasm: Stimulation of destroyed cells clearance using antigen-presenting cells (APC), stimulation of T cells and activation of high mobility group box 1 (HMGB1), but also activation of major histocompatibility complex (MHC-1) which facilitates the recognition of tumor cells by cytotoxic T lymphocyte are mechanisms by which the immune system is stimulated by irradiation.