ASXL1 and hematologic disorder: Recent studies using mice expressing an ASXL1 mutant, which generated a carboxy-terminal truncated ASXL1 protein, demonstrated that an ASXL1 mutation alone was not sufficient for inducing the development of hematologic malignancies, but increased the susceptibility to leukemogenesis in concert with a RUNX1 mutant or in viral insertional mutagenesis, indicating that mice expressing an ASXL1 mutant represent a premalignant condition [94].