In contrast, loss-of-function mutations in PRC genes, such as EZH2, EED, SUZ12, BCOR, and BCORL1, have been found in various hematological malignancies, suggesting their tumor suppressor functions (Table 1) [25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51]. The gene discussed is BCORL1; the disease is hematologic disorder.