We showed that an epigenetic switch from H3K27me3 to DNA methylation occurs at a significant portion of PRC2 targets following the loss of Ezh2 in Tet2 hypomorph (Tet2KD/KDEzh2Δ/Δ) mice, thereby maintaining their transcriptional repression to promote the progression of MDS [118]. This evidence concerns the gene EZH2 and myelodysplastic syndrome.