(ii) high FSHR or LHCGR mRNA expression is associated with increased PFS and OS in all ovarian cancer patients including high-grade disease, (iii) high FSHR expression in cancer cells and tumor associated blood vessels was associated with increased PFS and OS, (iv) both low FSHR and low LHCGR protein expression were associated with reduced PFS and OS in HGSOC patients, (v) FSHR knockdown increased invasion of OVCAR-3 cells and COV362 cells, and (vi) knockdown of LHCGR increased the invasion of COV362 cells. The gene discussed is LHCGR; the disease is cancer.