The Staphylococcus aureus infection pathway as second among the top KEGG pathways differentiating d-fVSCC and progVSCC proteomes (Figure S4), along with the microbicidal PRTN3 protein increase during the disease course, suggest that bacterial infections may be linked to aggressive VSCC phenotypes. The gene discussed is PRTN3; the disease is staphylococcus aureus infection.