ADH5 and neoplasm: Rizza et al. found that knockdown of S-nitrosoglutathione reductase resulted in mitochondrial defects and that S-nitrosoglutathione reductase deficient HepG2 cells and tumors were sensitive to succinate dehydrogenase inhibition, which induced RIP1/PARP1-mediated necroptosis and suppressed tumor growth [99].