PLAU and neoplasm: The GO enrichment analysis results of the high-level ESCC sample group showed that these genes are related to extracellular matrix, which is benefits to tumor proliferation, invasion and migration [32,33], suggesting that high levels of CXCL10, TNFAIP3, INHBA, and PLAU might affect the structure and composition of the extracellular matrix to promote ESCC progression.