While processing RNA-seq data of CXCL10, TNFAIP3, INHBA, and PLAU in ESCC samples, we noticed that the expression levels of these genes were correlated with each other, and as the p65 in the NFκB family is an established transcription factor, we hypothesized that these 4 genes might be directly regulated by p65 in ESCC. Here, PLAU is linked to esophageal squamous cell carcinoma.