The GO enrichment analysis results of the high-level ESCC sample group showed that these genes are related to extracellular matrix, which is benefits to tumor proliferation, invasion and migration [32,33], suggesting that high levels of CXCL10, TNFAIP3, INHBA, and PLAU might affect the structure and composition of the extracellular matrix to promote ESCC progression. Here, PLAU is linked to esophageal squamous cell carcinoma.