We have verified SCD, CDH3, MAP2K3 and GADD45B as the targets of SFE in ESCC through microarray analyses [9]; however, changing the expression of these genes could not completely reverse the inhibitory effect of SFE on ESCC proliferation and metastasis, which suggests that there must be some other mediators to connect SFE with ESCC characteristics. The gene discussed is MAP2K3; the disease is esophageal squamous cell carcinoma.