The GO enrichment analysis results of the high-level ESCC sample group showed that these genes are related to extracellular matrix, which is benefits to tumor proliferation, invasion and migration [32,33], suggesting that high levels of CXCL10, TNFAIP3, INHBA, and PLAU might affect the structure and composition of the extracellular matrix to promote ESCC progression. This evidence concerns the gene INHBA and esophageal squamous cell carcinoma.