Interestingly, we found that the expression levels of CXCL10, TNFAIP3, INHBA, and PLAU were significantly correlated with each other in the TCGA ESCC samples (Figure 3D), and considering that p65 of the NFκB family can regulate genes involved in the immune response, cell proliferation, differentiation, and metastasis as a transcription factor, we speculated that these 4 genes might be the direct downstream targets of p65 in ESCC. The gene discussed is TNFAIP3; the disease is esophageal squamous cell carcinoma.