IL2RG and Miyoshi myopathy: Subsequently, the introduction of intratibial injection methods, as well as the development of NOD/SCID-based highly immunodeficient mice, such as NOG (NOD/Shi-SCID/IL2Rγ−/−), and NSG (NOD/LtSz-SCID/IL2Rγ−/−), and Rag2−/−IL2Rγ−/− mice, has led to the improvement in the ability of BM engraftment of patient MM cells [132,133,134,135].