GLA and Fabry disease: Fabry disease (FD) is a rare, progressive, multisystemic, and X-linked inherited lysosomal disorder, caused by genetic variations in GLA (HUGO Gene Nomenclature Committee ID: 4296; Gene Entrez: 2717; NCBI reference sequence: NM_000169.2), which encodes α-galactosidase (α-Gal, Enzyme Commission number: EC 3.2.1.22; UniProt ID: P06280) [1,2].