CXCL8 and obesity due to melanocortin 4 receptor deficiency: What is more, patients suffering from obesity with NASH present a decreased number of Faecalibacterium [46], which possesses anti-inflammatory properties due to the production of NF-kB and interleukin-8 (IL-8) inhibitors and acts locally in the colon by means of anti-inflammatory cytokine induction [47].