Furthermore, 70–80% of T cells in the tumor microenvironment of ML/CT-2A tumors exhibit prolonged expression of T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) and lymphocyte-activation gene 3 (LAG-3), both markers for dysfunctional T cells [33]. The gene discussed is HAVCR2; the disease is neoplasm.