The expression of Acsm2, encoding mitochondrial acyl-coenzyme A synthetase for medium-chain fatty acids 2, which has been related to insulin resistance [23], was inhibited in the MCD diet groups as well as in TNAP+/− control mice, while that of Acot5, encoding an acyl-coenzyme A thioesterase, was enhanced only in TNAP+/− control mice. The gene discussed is ALPL; the disease is Insulin resistance.