Binding of BubR1 to Cdc20 blocks APC activity by triggering a “wait anaphase” signal [58,59], thus contributing to the development of polyploid cells, extended cell survival, and uncontrolled cell proliferation, suggesting a plausible pathogenic mechanism in the initiation of CIN in CRC sporadic forms [60]. Here, BUB1B is linked to colorectal carcinoma.