APC and colorectal carcinoma: Many genes are identified to be methylated and silenced in CRC, some commonly methylated ones include APC, MLH1, MGMT, SFRP1, SFRP2, CDKN2A, TIMP3, VIM, SEPT, CDH1 and HLTF. Additionally, there is a distinct subset of CRCs, known as the CpG island methylator phenotype (CIMP) [133]; CIMP tumors frequently carry BRAFV600E mutations [134].