The second group consisted of non-hypermutated tumors (~84%), microsatellite stable (MSS) cancers with a high frequency of DNA somatic copy number alterations (SCNAs) and dysregulated Wnt pathway with frequent mutations in genes including Adenomatous polyposis coli (APC), Kirsten ras (KRAS), Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA), Small mothers against decapentaplegic 4 (SMAD4), and Tumor protein 53 (TP53) [3]. The gene discussed is APC; the disease is cancer.