KDR and osteosarcoma: Results from experiments in cervical, renal, non-small-cell lung, osteosarcoma, and hepatocellular cancer cells show that miR-497-5p regulates cell growth and proliferation and is associated with the MAPK pathway by targeting several involved genes such as RAF1, KDR/VGFR-2, and IGF1-R [17,18,19,20,21].