At mid gestation, overweight or obese mothers with PCOS showed significantly lower insulin sensitivity (median PREDIM levels: 0.56, IQR: 0.33–0.67) compared to normal weight PCOS women (1.12, IQR: 1.02–1.20, p = 0.002) or controls (1.03, IQR 0.94–1.33, p = 0.004), whereas no differences were observed compared to overweight or obese women without PCOS (0.92, IQR 0.42–1.05, p = 0.528). This evidence concerns the gene INS and polycystic ovary syndrome.