In addition, feeding of NOD mice with SCFA even at the onset of T1D gave them protection against T1D, by lowering the number of islets auto-reactive T cells and enhancing the proliferation of FoxP3+ Treg cells in the gut mucosa, spleen, and pancreatic lymph nodes, thus enhancing immune tolerance [173,181]. Here, FOXP3 is linked to type 1 diabetes mellitus.