Taken together that hepatitis seropositivity is associated with DLBCL, CLL and MZL risk and that AICDA promiscuous off-target activity, highly present in lymphomas and induced by viral infection, can provoke important alterations (example translocations of PD-L1/PD-L2 with PIM1, TP63, and IGH loci). Here, PDCD1LG2 is linked to B-cell chronic lymphocytic leukemia.