RUNX2 and neoplasm: Li Zhang et al. discovered that the tumor tissue produces BMP-2 locally through autocrine or paracrine ways, which combines with related receptors and enters the nucleus, acts at the target gene, and then regulates RUNX2, OPN, and other bone matrix proteins to form a microenvironment of calcium and phosphorus deposits in the tumor tissue, resulting in the formation of microcalcifications [51].