Mishra et al. showed that there was no difference in the cecal bacterial microbiota composition and load between ADAM17 conditional KO mice and control mice, but the conditional knockout of ADAM17 decreased the peritoneal spread of bacteria following sepsis induction compared to control mice [196], which might be involved with reduced cleavages of TNF-α shedding and other proinflammatory cytokines by ADAM17. The gene discussed is ADAM17; the disease is Sepsis.