APP and Alzheimer disease: The β-site APP cleaving enzyme 1 (BACE1) and γ-secretases induce the amyloidogenic pathway, where APP is cleaved extracellularly to create a soluble fraction, sAPPβ, the main component of AD plaques, Amyloid β-peptide (Aβ) and Amyloid Precursor Intracellular Domain (AICD) [72].