TCF7L2 and Familial prostate cancer: Exon 3 in MYC is highly conserved across species, and we previously reported a variety of characteristics that are common to transcriptional regulatory regions within 2 kb of the MYC exon 3 CpG sites in various prostate cancer cell lines using ENCODE data, which included DNaseI HS peaks, histone methylation and acetylation marks and TFBS for ETV1 and TCF7L2 [28].