CASC11 and neoplasm: Our observations of lower MYC DNA methylation in tumor tissue and inverse MYC methylation associations with PRNCR1 and CASC11 thus appear to be in line with the biology of these ncRNAs (i.e., if MYC methylation is lower in tumor than normal tissue and inversely associated with these lncRNAs, then we would expect to see increased expression of these lncRNAs in tumor, as we and others have observed).