Expanding on these findings, Du and colleagues examined physical interactions across the genome for several 8q24 cancer susceptibility regions using a chromosome conformation capture (3C)-based, multi-target sequencing technology in cell lines for a variety of cancers (including prostate) and found frequent interactions with MYC as well as other intra- and inter-chromosomal targets; other common intra-chromosomal targets included PVT1, FAM84B and GSDMC [21]. This evidence concerns the gene PVT1 and cancer.