MYC and neoplasm: Among the University of Maryland tumor samples, we observed significantly lower MYC DNA methylation for more aggressive tumors (GS 7) than less aggressive tumors (GS 6) for three exon 3 CpG sites (for CpG 212 (chr8:128753145), median % DNA methylation for GS 6 group = 89.7%; median for GS 7 group = 85.8%; p-value = 9.4 × 10−4 (Figure 2)).