MYC and Familial prostate cancer: Based on the importance of the 8q region and the MYC gene in prostate carcinogenesis/progression [13,40], we investigated the role of MYC DNA methylation (six CpG sites spanning from exon 3 to the 3′ UTR) in prostate tumor tissue from African American and Caucasian prostate cancer patients who underwent radical prostatectomy at the University of Maryland Medical Center.